史瑜

史瑜，2022年博士毕业于华南农业大学，2022年10月-2024年9月在华南农业大学从事博士后研究，同月以A类博士被引进到永利yl23411no1生命科学学院工作，主要从事植物病原菌致病机理及病害防控的研究，其中以第一作者（包括共同一作）和通讯作者（包括共同通讯）在Molecular Plant Pathology、Chinese Chemistry Letters、 Journal of Agricultural and Food Chemistry、Bioorganic Chemistry和International Journal of Molecular Sciences等期刊发表SCI论文7篇（一区5篇，二区2篇），其中单篇最高影响因子9.4。

植物病原菌致病机制及病害防控

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1. 国家自然科学基金面上项目（32472589）：水稻细菌性基腐病VFM群体感应抑制剂的设计合成及作用机制研究，2025年1月1日-2028年12月31日，在研，第一参与人。

2. 湖北省重点实验室开放课题（RNG202306）: 水稻白叶枯病菌T3SS抑制剂的筛选和活性研究。2023年12月-2025年12月，在研，主持。

3. 广东省微生物信号与作物病害防控重点实验室开放课题：水稻白叶枯病菌III型分泌系统抑制剂作用靶标的发现与作用机制的研究，2023年12月-2025年12月，在研，主持。

代表性论文：

1) Yu Shi#, Zhao-Sheng Zhang#,Jiang Shao#, Chen Fu, Lan-Tu Xiong, Zhaodong Li* and Zi-Ning Cui*.Photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination compounds as potential bactericidal agent against Xanthomonas oryzae pv.oryzae, Chin Chem Lett 2024,35(1): 108794. (中科院一区Top, IF: 9.4)

2) Yu Shi, Tianfang Cheng, Qing wei Cheang, Xiaoyan Zhao, Zhao-xun Liang, Linghui Xu* and Junxia Wang*. A cyclic di-GMP-binding adaptor protein interacts with a N5-glutamine methyltransferase to regulate the pathogenesis in Xanthomonas citri subsp. citri, Mol Plant Pathol 2024, 25(7): e13496. (中科院一区Top, IF:4.9)

3) Yu Shi#, Lan-Tu Xiong#,Hui Li#, Wen-Long Li#, Dylan O'Neill Rothenberg, Li-ShengLiao, Xin Deng, Gao-Peng Song* and Zi-Ning Cui*. Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG–HrpX regulatory cascade, Bioorg Chem 2023, 141: 106871. (中科院二区Top,IF:5.1)

4) Yu Shi, Xiaobei Yang, Xiaoxin Ye, Jiaying Feng, Tianfang Cheng, Xiaofan Zhou, Ding Xiang Liu, Linghui Xu* and Junxia Wang*. The methyltransferase HemK regulates the virulence and nutrient utilization of the phytopathogenic bacterium Xanthomonas citri subsp. citri, Int J Mol Sci 2022,23 (7), 3931.(中科院二区Top, IF:6.2)

5) Lu-Lu He; Lan-Tu Xiong; Xin Wang; Yu-Zhen Li; Jia-Bao Li; Yu Shi*; Xin Deng; Zi-Ning Cui*. Application of Inhibitors Targeting the Type III Secretion System in Phytopath ogenic Bacteria.Chin Chem Lett 2025,36(4): 110044. (中科院一区Top, IF:9.4)

6) Jiang Shao#, Zhi-Jun Zhang#, Yu Shi#,Wei-Qi Jiang, Faisal Siddique,Liangye Chen, Genyan Liu,Jiakai Zhu, Xiong-Fei Luo, Ying-Qian Liu*, Jun-Xia An, Cheng-Jie Yang, Zi-Ning Cui*. Application and mechanism of cryptolepine and neocryptolepine derivatives as T3SS inhibitors for control of bacterial leaf blight on rice. Journal of Agricultural and Food Chemistry, J Agric Food Chem 2024, 72(13):6988-6997. (中科院一区Top, IF:6.1)

7) Zhao-Sheng Zhang#, Zhe He#, Yu Shi#,Ming-Ming Guan#, Di Zhu, Ya-Sheng Li, Xin Deng, Zi-Ning Cui*.Structure-based discovery of symmetric disulfides from garlic extract as Pseudomonas aeruginosa quorum sensing inhibitors.J Agric Food Chem2024, 72 (37), 20299-20307. (中科院一区Top, IF:6.1)

8) Jinxing Wei, Linghui Xu, Yu Shi, Tianfang Cheng, Wenlan Tan, Yongguo Zhao, Chunsheng Li, Xinyu Yang, Lejun Ouyang, Mingken Wei, Junxia Wang* and Guangyuan Lu*. Transcriptome profile analysis of Indian mustard (Brassica juncea L.) during seed germination reveals the drought stress-induced genes associated with energy, hormone, and phenylpropanoid pathways. Plant Physiology Biochemistry, 2023, 200,107750.

9) Tianfang Cheng, Qing wei Cheang, Linghui Xu, Shuo Sheng, Zhaoting Li, Yu Shi, Huiyan Zhang, Li Mei Pang, Ding Xiang Liu, Liang Yang, Zhao-xun Liang*and Junxia Wang*. A pilZ domain protein interacts with the transcriptional regulator HinK to regulate type VI secretion system in Pseudomonas aeruginosa, Journal of Biological Chemistry, 2024,1016,105741.

10) Zhe Zhou, Xiaozhen Wu, Jiayi Li, Yiyin Zhang, YaohuaHuang, Wenping Zhang, Yu Shi, Junxia Wang* and Shaohua Chen*. A novel quorum quencher, Rhodococcus pyridinivorans XN-36, is a powerful agent for the biocontrol of soft rot disease in various host plants. Biological Control, 2022,169,104889.